Brain studied the craft of the artist at the same time with Joos van Cleve, Jan Yost, working in Wesel, Kalkara and Verdun, before he moved to Cologne. Between 1515 and 1520 brain married a girl named Agnes with whom he had five children. From 1512 he worked in the shop of the so-called masters of SV. Severin, however, the first documented mention of its activities in Cologne refers to the 1515. But after three years, the brain becomes a member of the extended municipality.