The oldest pieces in the collection are German sculptures from the 12th to 16th century. This includes works by Tilman Riemenschneider, Hendrik Douvermann and Arndt van Tricht. Paintings from the 16th century include a Judith by Luca Cranach the Elder, an Ecce Homo and Mater Dolorosa Diptych by Aelbrecht Bouts and a Mary Magdalen by Cornelis Engebrechtsz.. Major artists from the 17th century who are represented here include from Spain Francisco de Zurbarán, Luis de Morales and Jusepe de Ribera and from Italy Bartolomeo Manfredi. The large collection of paintings from Flanders and the Netherlands shows works by Anthony van Dyck, Jacob Jordaens, Frans Snyders, Jacob Isaacksz van Ruisdael, Frans Hals, Willem Claeszoon Heda, Willem Kalf, Joseph de Bray and Jan Boeckhorst.
The modern art collection is largely restricted to artists living or working in Germany, including internationally known ones like Alexej von Jawlensky, Otto Dix, Max Beckmann, August Macke and Andreas Achenbach.